A Role of Tec , a Non Receptor Tyrosine Kinase as Apoptotic Regulator

نویسندگان

  • Khushbu Patel
  • Jayvadan K. Patel
  • Anita Patel
  • Aaishwarya Deshmukh
  • Bharat Mishra
چکیده

There are many types of tyrosine kinase involved in intracellular mitogenic mechanism, particularly, Tec tyrosine kinase are involved in apoptosis pathway. Tec tyrosine kinases do not have any transmembrane domain so it is known as non receptor tyrosine kinase. There are various types of Tec tyrosine kinase like Txk, Btk, Itk, Rik and Bmx. These kinases have different protein or domain structure like PH domain, SH2 domain, SH3 domain TH domain and also chromosome localization. Tec tyrosine kinase is mainly expressed in spleen, liver, kidney and heart but low in many others tissues. Activation of Tec tyrosine kinase cause by the different molecule like PKCs, JAK, SFK and FADD. Regulation of Tec tyrosine kinase cause by CD+4 native cell and CD+4 activated cell, and also involve IL-12, IL-27, IFNγ, IL-18 and IL-4. There are various downstream and upstream regulators involved in Tec tyrosine kinase family. The role of Tec tyrosine kinase is Induction of Bcl-xL, Mitogenic signals in T-cells, Tec kinases as a RhoA regulator, Regulation of apoptosis, Control of c-fos transcription. There are various diseases produce due to lack of T-cell and B-cell like Behcet’s disease, XLA and XID.

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تاریخ انتشار 2011